Pathogenic T cell responses against aquaporin 4
نویسندگان
چکیده
منابع مشابه
Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica.
In neuromyelitis optica (NMO), B-cell autoimmunity to aquaporin-4 (AQP4) has been shown to be essential. However, the role of T cells remains ambiguous. Here, we first showed an increase in CD69+ activated T cells in PBMCs during NMO relapses. Next, T-cell responses to AQP4 and myelin peptides were studied in 12 NM0 patients, 10 multiple sclerosis (MS) patients and 10 healthy subjects (HS). Fou...
متن کاملPathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica
INTRODUCTION Neuromyelitis Optica (NMO) is an autoimmune disease primarily targeting the spinal cord and optic nerve leading to paralysis and blindness. The discovery of an antibody against the astrocytic water channel, aquaporin-4 (AQP4), in the majority of patients, has led to the presumption that the antibody was necessary for disease pathogenesis. The potential role of T cells in the centra...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2011
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-011-0824-0